| Language | English |
| Book Subtitle | Synthesis And Biological Evaluation |
| Book Description | In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation. |
| Editorial Review | From the reviews: "this is a neat little book giving a good overview of the world of mucosal vaccines. ... Each chapter has a comprehensive list of references and some pleasing figures ... . I would recommend that any institution working on vaccine development should invest in a copy. It would be particularly useful for a first year phd student embarking on a vaccine development project." (helen ambrose, microbiology today, november, 2012) |
| Number of Pages | 130 |
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